2FDA
Crystal Structure of the Catalytic Domain of Human Coagulation Factor XIa in Complex with alpha-Ketothiazole Arginine Derived Ligand
Summary for 2FDA
Entry DOI | 10.2210/pdb2fda/pdb |
Related | 1ZHR 1ZPB 1ZPC |
Descriptor | Coagulation factor XI, BICARBONATE ION, SULFATE ION, ... (5 entities in total) |
Functional Keywords | fxia, inhibitor, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P03951 |
Total number of polymer chains | 1 |
Total formula weight | 27355.95 |
Authors | Jin, L.,Pandey, P.,Babine, R.E.,Weaver, D.T.,Abdel-Meguid, S.S.,Strickler, J.E. (deposition date: 2005-12-13, release date: 2006-04-18, Last modification date: 2023-08-30) |
Primary citation | Deng, H.,Bannister, T.D.,Jin, L.,Babine, R.E.,Quinn, J.,Nagafuji, P.,Celatka, C.A.,Lin, J.,Lazarova, T.I.,Rynkiewicz, M.J.,Bibbins, F.,Pandey, P.,Gorga, J.,Meyers, H.V.,Abdel-Meguid, S.S.,Strickler, J.E. Synthesis, SAR exploration, and X-ray crystal structures of factor XIa inhibitors containing an alpha-ketothiazole arginine Bioorg.Med.Chem.Lett., 16:3049-3054, 2006 Cited by PubMed: 16524727DOI: 10.1016/j.bmcl.2006.02.052 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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