1ZPC
Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 2-[2-(3-Chloro-phenyl)-2-hydroxy-acetylamino]-N-[4-guanidino-1-(thiazole-2-carbonyl)-butyl]-3-methyl-butyramide
Summary for 1ZPC
Entry DOI | 10.2210/pdb1zpc/pdb |
Related | 1ZPB |
Descriptor | Coagulation factor XI, SULFATE ION, 2-[2-(3-CHLORO-PHENYL)-2-HYDROXY-ACETYLAMINO]-N-[4-GUANIDINO-1-(THIAZOLE-2-CARBONYL)-BUTYL]-3-METHYL-BUTYRAMIDE, ... (4 entities in total) |
Functional Keywords | fxi, inhibitor, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P03951 |
Total number of polymer chains | 1 |
Total formula weight | 27547.56 |
Authors | Deng, H.,Bannister, T.D.,Jin, L.,Nagafuji, P.,Celatka, C.A.,Lin, J.,Lazarova, T.I.,Rynkiewicz, M.J.,Quinn, J.,Bibbins, F.,Pandey, P.,Gorga, J.,Babine, R.E.,Meyers, H.V.,Abdel-Meguid, S.S.,Strickler, J.E. (deposition date: 2005-05-16, release date: 2006-04-18, Last modification date: 2023-08-23) |
Primary citation | Deng, H.,Bannister, T.D.,Jin, L.,Babine, R.E.,Quinn, J.,Nagafuji, P.,Celatka, C.A.,Lin, J.,Lazarova, T.I.,Rynkiewicz, M.J.,Bibbins, F.,Pandey, P.,Gorga, J.,Meyers, H.V.,Abdel-Meguid, S.S.,Strickler, J.E. Synthesis, SAR exploration, and X-ray crystal structures of factor XIa inhibitors containing an alpha-ketothiazole arginine Bioorg.Med.Chem.Lett., 16:3049-3054, 2006 Cited by PubMed: 16524727DOI: 10.1016/j.bmcl.2006.02.052 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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