2FCC

Crystal Structure of T4 Pyrimidine Dimer Glycosylase (T4-Pdg) Covalently Complexed with a DNA Substrate Containing Abasic Site

Summary for 2FCC

• Entry DOI: 10.2210/pdb2fcc/pdb
• Descriptor: DNA (5'-D(*CP*CP*AP*GP*GP*AP*(PED)P*GP*AP*AP*GP*CP*C)-3'), DNA (5'-D(*GP*GP*CP*(BRU)P*(BRU)P*CP*AP*(BRU)P*CP*CP*(BRU)P*GP*G)-3'), Endonuclease V, ... (6 entities in total)
• Functional Keywords: t4-pdg, pyrimidine dimer, dna repair, endonuclease, enzyme-dna complex, covalent intermediate, hydrolase
• Biological source: Enterobacteria phage T4; More
• Total number of polymer chains: 6
• Total formula weight: 48486.23

Authors

Golan, G.,Zharkov, D.O.,Fernandes, A.S.,Dodson, M.L.,McCullough, A.K.,Grollman, A.P.,Lloyd, R.S.,Shoham, G. (deposition date: 2005-12-12, release date: 2006-10-03, Last modification date: 2023-08-30)

• Primary citation: Golan, G.,Zharkov, D.O.,Grollman, A.P.,Dodson, M.L.,McCullough, A.K.,Lloyd, R.S.,Shoham, G.; Structure of T4 Pyrimidine Dimer Glycosylase in a Reduced Imine Covalent Complex with Abasic Site-containing DNA.; J.Mol.Biol., 362:241-258, 2006; PubMed: 16916523; DOI: 10.1016/j.jmb.2006.06.059

Experimental method

X-RAY DIFFRACTION (2.3 Å)