2F9U

HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with a P2 norborane

2F9U の概要

関連するPDBエントリー1A1R 1JXP 2A4G 2A4Q 2A4R 1N1L
分子名称NS3 protease/helicase', polyprotein, ZINC ION, ... (5 entities in total)
機能のキーワードhcv, hepatitis c protease, ns3 protease, ketoamide inhibitor, viral protein
由来する生物種Hepatitis C virus
詳細
ポリマー鎖数4
分子量合計47861.86
構造登録者
Venkatraman, S.,Njoroge, F.G.,Wu, W.,Girijavallabhan, V.,Prongay, A.J.,Butkiewicz, N.,Pichardo, J. (登録日: 2005-12-06, 公開日: 2006-06-06, 最終更新日: 2011-07-13)
主引用文献
Venkatraman, S.,Njoroge, F.G.,Wu, W.,Girijavallabhan, V.,Prongay, A.J.,Butkiewicz, N.,Pichardo, J.
Novel Inhibitors of Hepatitis C NS3-NS4A Serine Protease Derived from 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid.
Bioorg.Med.Chem.Lett., 16:1628-1632, 2006
PubMed: 16413182 (主引用文献が同じPDBエントリー)
DOI: 10.1016/j.bmcl.2005.12.046
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.6 Å)
NMR情報
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.203151.1%6.5%2.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード