2F9P

Crystal Structure of the Recombinant Human Alpha I Tryptase Mutant D216G in Complex with Leupeptin

Summary for 2F9P

• Entry DOI: 10.2210/pdb2f9p/pdb
• Related: 2F9N 2F9O
• Related PRD ID: PRD_000216
• Descriptor: Tryptase alpha-1, Leupeptin, alpha-L-fucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: serine proteinase, leupeptin, trypsin-like, difucosylation, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 113310.12

Authors

Rohr, K.B.,Selwood, T.,Marquardt, U.,Huber, R.,Schechter, N.M.,Bode, W.,Than, M.E. (deposition date: 2005-12-06, release date: 2006-01-31, Last modification date: 2023-08-30)

• Primary citation: Rohr, K.B.,Selwood, T.,Marquardt, U.,Huber, R.,Schechter, N.M.,Bode, W.,Than, M.E.; X-ray Structures of Free and Leupeptin-complexed Human alpha I-Tryptase Mutants: Indication for an alpha to beta-Tryptase Transition; J.Mol.Biol., 357:195-209, 2005; PubMed: 16414069; DOI: 10.1016/j.jmb.2005.12.037

Experimental method

X-RAY DIFFRACTION (2.3 Å)