2F8X

Crystal structure of activated Notch, CSL and MAML on HES-1 promoter DNA sequence

2F8X の概要

• エントリーDOI: 10.2210/pdb2f8x/pdb
• 分子名称: 5'-D(*GP*TP*TP*AP*CP*TP*GP*TP*GP*GP*GP*AP*AP*AP*GP*AP*AP*A)-3', 5'-D(*TP*TP*TP*CP*TP*TP*TP*CP*CP*CP*AP*CP*AP*GP*TP*AP*AP*C)-3', Recombining binding protein suppressor of hairless, isoform 4, ... (6 entities in total)
• 機能のキーワード: notch, csl, mastermind, hes-1, ankyrin repeats, rel-homology region, transcription-dna complex, transcription/dna
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: Q06330; Cell membrane; Single-pass type I membrane protein (By similarity). Notch 1 intracellular domain: Nucleus (By similarity): P46531; Nucleus speckle: Q92585
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 95742.19

構造登録者

Nam, Y.,Sliz, P.,Blacklow, S.C. (登録日: 2005-12-04, 公開日: 2006-04-04, 最終更新日: 2023-08-30)

• 主引用文献: Nam, Y.,Sliz, P.,Song, L.,Aster, J.C.,Blacklow, S.C.; Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.; Cell(Cambridge,Mass.), 124:973-983, 2006; PubMed: 16530044; DOI: 10.1016/j.cell.2005.12.037

実験手法

X-RAY DIFFRACTION (3.25 Å)