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2F6V

Protein tyrosine phosphatase 1B with sulfamic acid inhibitors

Summary for 2F6V
Entry DOI10.2210/pdb2f6v/pdb
Related2F6T 2F6W 2F6Y 2F6Z 2F70 2F71
DescriptorTyrosine-protein phosphatase, non-receptor type 1, MAGNESIUM ION, CHLORIDE ION, ... (5 entities in total)
Functional Keywordsptp1b, sulfamic acids, tetrahydroisoquinoline, phosphatase, tyrosine, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationEndoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
Total number of polymer chains1
Total formula weight35341.59
Authors
Evdokimov, A.G.,Pokross, M.E.,Klopfenstein, S.R. (deposition date: 2005-11-29, release date: 2005-12-13, Last modification date: 2023-08-23)
Primary citationKlopfenstein, S.R.,Evdokimov, A.G.,Colson, A.-O.,Fairweather, N.T.,Neuman, J.J.,Maier, M.B.,Gray, J.L.,Gerwe, G.S.,Stake, G.E.,Howard, B.W.,Farmer, J.A.,Pokross, M.E.,Downs, T.R.,Kasibhatla, B.,Peters, K.G.
1,2,3,4-Tetrahydroisoquinolinyl sulfamic acids as phosphatase PTP1B inhibitors
Bioorg.Med.Chem.Lett., 16:1574-1578, 2006
Cited by
PubMed: 16386905
DOI: 10.1016/j.bmcl.2005.12.051
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.7 Å)
Structure validation

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