2F6W
Protein tyrosine phosphatase 1B with sulfamic acid inhibitors
Summary for 2F6W
Entry DOI | 10.2210/pdb2f6w/pdb |
Related | 2F6T 2F6V 2F6Y 2F6Z 2F70 2F71 |
Descriptor | Tyrosine-protein phosphatase, non-receptor type 1, MAGNESIUM ION, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | ptp1b, sulfamic acids, tetrahydroisoquinoline, phosphatase, tyrosine, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031 |
Total number of polymer chains | 1 |
Total formula weight | 35175.41 |
Authors | Evdokimov, A.G.,Pokross, M.E.,Klopfenstein, S.R. (deposition date: 2005-11-29, release date: 2005-12-13, Last modification date: 2023-08-23) |
Primary citation | Klopfenstein, S.R.,Evdokimov, A.G.,Colson, A.-O.,Fairweather, N.T.,Neuman, J.J.,Maier, M.B.,Gray, J.L.,Gerwe, G.S.,Stake, G.E.,Howard, B.W.,Farmer, J.A.,Pokross, M.E.,Downs, T.R.,Kasibhatla, B.,Peters, K.G. 1,2,3,4-Tetrahydroisoquinolinyl sulfamic acids as phosphatase PTP1B inhibitors Bioorg.Med.Chem.Lett., 16:1574-1578, 2006 Cited by PubMed: 16386905DOI: 10.1016/j.bmcl.2005.12.051 PDB entries with the same primary citation |
Experimental method |
Structure validation
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