2F4B
Crystal structure of the ligand binding domain of human PPAR-gamma in complex with an agonist
Summary for 2F4B
Entry DOI | 10.2210/pdb2f4b/pdb |
Descriptor | Peroxisome proliferator-activated receptor gamma, (5-{3-[(6-BENZOYL-1-PROPYL-2-NAPHTHYL)OXY]PROPOXY}-1H-INDOL-1-YL)ACETIC ACID (3 entities in total) |
Functional Keywords | ppar, transcription activator |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P37231 |
Total number of polymer chains | 2 |
Total formula weight | 62515.65 |
Authors | Lu, I.L.,Peng, Y.H.,Mahindroo, N.,Hsieh, H.P.,Wu, S.Y. (deposition date: 2005-11-23, release date: 2006-02-14, Last modification date: 2024-03-13) |
Primary citation | Mahindroo, N.,Wang, C.C.,Liao, C.C.,Huang, C.F.,Lu, I.L.,Lien, T.W.,Peng, Y.H.,Huang, W.J.,Lin, Y.T.,Hsu, M.C.,Lin, C.H.,Tsai, C.H.,Hsu, J.T.,Chen, X.,Lyu, P.C.,Chao, Y.S.,Wu, S.Y.,Hsieh, H.P. Indol-1-yl Acetic Acids as Peroxisome Proliferator-Activated Receptor Agonists: Design, Synthesis, Structural Biology, and Molecular Docking Studies J.Med.Chem., 49:1212-1216, 2006 Cited by PubMed: 16451087DOI: 10.1021/jm0510373 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.07 Å) |
Structure validation
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