2F3K
Substrate envelope and drug resistance: crystal structure of r01 in complex with wild-type hiv-1 protease
Summary for 2F3K
Entry DOI | 10.2210/pdb2f3k/pdb |
Descriptor | Protease, PHOSPHATE ION, (3S,4AS,8AS)-N-(TERT-BUTYL)-2-[(3S)-3-({3-(METHYLSULFONYL)-N-[(PYRIDIN-3-YLOXY)ACETYL]-L-VALYL}AMINO)-2-OXO-4-PHENYLBUTYL]DECAHYDROISOQUINOLINE-3-CARBOXAMIDE, ... (4 entities in total) |
Functional Keywords | substrate envelope, drug resistance, hiv protease, ro1, hydrolase |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369 |
Total number of polymer chains | 2 |
Total formula weight | 22818.35 |
Authors | Prabu-Jeyabalan, M.,King, N.M.,Nalivaika, E.A.,Heilek-Snyder, G.,Cammack, N.,Schiffer, C.A. (deposition date: 2005-11-21, release date: 2006-11-21, Last modification date: 2023-08-23) |
Primary citation | Prabu-Jeyabalan, M.,King, N.M.,Nalivaika, E.A.,Heilek-Snyder, G.,Cammack, N.,Schiffer, C.A. Substrate envelope and drug resistance: crystal structure of RO1 in complex with wild-type human immunodeficiency virus type 1 protease. Antimicrob.Agents Chemother., 50:1518-1521, 2006 Cited by PubMed: 16569872DOI: 10.1128/AAC.50.4.1518-1521.2006 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.599 Å) |
Structure validation
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