2F3K

Substrate envelope and drug resistance: crystal structure of r01 in complex with wild-type hiv-1 protease

2F3K の概要

• エントリーDOI: 10.2210/pdb2f3k/pdb
• 分子名称: Protease, PHOSPHATE ION, (3S,4AS,8AS)-N-(TERT-BUTYL)-2-[(3S)-3-({3-(METHYLSULFONYL)-N-[(PYRIDIN-3-YLOXY)ACETYL]-L-VALYL}AMINO)-2-OXO-4-PHENYLBUTYL]DECAHYDROISOQUINOLINE-3-CARBOXAMIDE, ... (4 entities in total)
• 機能のキーワード: substrate envelope, drug resistance, hiv protease, ro1, hydrolase
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22818.35

構造登録者

Prabu-Jeyabalan, M.,King, N.M.,Nalivaika, E.A.,Heilek-Snyder, G.,Cammack, N.,Schiffer, C.A. (登録日: 2005-11-21, 公開日: 2006-11-21, 最終更新日: 2023-08-23)

• 主引用文献: Prabu-Jeyabalan, M.,King, N.M.,Nalivaika, E.A.,Heilek-Snyder, G.,Cammack, N.,Schiffer, C.A.; Substrate envelope and drug resistance: crystal structure of RO1 in complex with wild-type human immunodeficiency virus type 1 protease.; Antimicrob.Agents Chemother., 50:1518-1521, 2006; PubMed: 16569872; DOI: 10.1128/AAC.50.4.1518-1521.2006

実験手法

X-RAY DIFFRACTION (1.599 Å)