2F3K
Substrate envelope and drug resistance: crystal structure of r01 in complex with wild-type hiv-1 protease
2F3K の概要
エントリーDOI | 10.2210/pdb2f3k/pdb |
分子名称 | Protease, PHOSPHATE ION, (3S,4AS,8AS)-N-(TERT-BUTYL)-2-[(3S)-3-({3-(METHYLSULFONYL)-N-[(PYRIDIN-3-YLOXY)ACETYL]-L-VALYL}AMINO)-2-OXO-4-PHENYLBUTYL]DECAHYDROISOQUINOLINE-3-CARBOXAMIDE, ... (4 entities in total) |
機能のキーワード | substrate envelope, drug resistance, hiv protease, ro1, hydrolase |
由来する生物種 | Human immunodeficiency virus 1 |
細胞内の位置 | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 22818.35 |
構造登録者 | Prabu-Jeyabalan, M.,King, N.M.,Nalivaika, E.A.,Heilek-Snyder, G.,Cammack, N.,Schiffer, C.A. (登録日: 2005-11-21, 公開日: 2006-11-21, 最終更新日: 2023-08-23) |
主引用文献 | Prabu-Jeyabalan, M.,King, N.M.,Nalivaika, E.A.,Heilek-Snyder, G.,Cammack, N.,Schiffer, C.A. Substrate envelope and drug resistance: crystal structure of RO1 in complex with wild-type human immunodeficiency virus type 1 protease. Antimicrob.Agents Chemother., 50:1518-1521, 2006 Cited by PubMed: 16569872DOI: 10.1128/AAC.50.4.1518-1521.2006 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.599 Å) |
構造検証レポート
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