2F16

Crystal structure of the yeast 20S proteasome in complex with bortezomib

2F16 の概要

• エントリーDOI: 10.2210/pdb2f16/pdb
• 関連するPDBエントリー: 1PMA 1RYP
• 分子名称: Proteasome component Y7, Proteasome component C11, Proteasome component PRE2, ... (16 entities in total)
• 機能のキーワード: beta-sandwich flanked by helices, complex structure covalently bound to the synthetic inihibtor bortezomib, hydrolase
• 由来する生物種: Saccharomyces cerevisiae (baker's yeast); 詳細
• 細胞内の位置: Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
• タンパク質・核酸の鎖数: 28
• 化学式量合計: 706511.66

構造登録者

Groll, M. (登録日: 2005-11-14, 公開日: 2006-03-21, 最終更新日: 2023-08-23)

• 主引用文献: Groll, M.,Berkers, C.R.,Ploegh, H.L.,Ovaa, H.; Crystal Structure of the Boronic Acid-Based Proteasome Inhibitor Bortezomib in Complex with the Yeast 20S Proteasome.; Structure, 14:451-456, 2006; PubMed: 16531229; DOI: 10.1016/j.str.2005.11.019

実験手法

X-RAY DIFFRACTION (2.8 Å)