2EXG
Making Protein-Protein Interactions Drugable: Discovery of Low-Molecular-Weight Ligands for the AF6 PDZ Domain
Summary for 2EXG
Entry DOI | 10.2210/pdb2exg/pdb |
Descriptor | Afadin, (5R)-2-SULFANYL-5-[4-(TRIFLUOROMETHYL)BENZYL]-1,3-THIAZOL-4-ONE (2 entities in total) |
Functional Keywords | inhibitors of protein-protein interactions, low-molecular-weight ligands, protein structure, nmr screening, pdz domains, cell adhesion |
Biological source | Homo sapiens (human) |
Cellular location | Cell junction, adherens junction: P55196 |
Total number of polymer chains | 1 |
Total formula weight | 10684.30 |
Authors | Joshi, M.,Vargas, C.,Boisguerin, P.,Krause, G.,Schade, M.,Oschkinat, H. (deposition date: 2005-11-08, release date: 2006-10-17, Last modification date: 2024-05-22) |
Primary citation | Joshi, M.,Vargas, C.,Boisguerin, P.,Diehl, A.,Krause, G.,Schmieder, P.,Moelling, K.,Hagen, V.,Schade, M.,Oschkinat, H. Discovery of low-molecular-weight ligands for the AF6 PDZ domain. Angew.Chem.Int.Ed.Engl., 45:3790-3795, 2006 Cited by PubMed: 16671149DOI: 10.1002/anie.200503965 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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