2EXG
Making Protein-Protein Interactions Drugable: Discovery of Low-Molecular-Weight Ligands for the AF6 PDZ Domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Afadin | polymer | 101 | 10393.0 | 1 | UniProt (P55196) Pfam (PF00595) | Homo sapiens (human) | AF-6 protein |
| 2 | B (A) | (5R)-2-SULFANYL-5-[4-(TRIFLUOROMETHYL)BENZYL]-1,3-THIAZOL-4-ONE | non-polymer | 291.3 | 1 | Chemie (STF) |
Sequence modifications
A: 6 - 101 (UniProt: P55196)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | cloning artifact |
| Pro 2 | - | cloning artifact |
| Leu 3 | - | cloning artifact |
| Gly 4 | - | cloning artifact |
| Ser 5 | - | cloning artifact |
| Val 53 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 10393.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 291.3 | |
| All* | Total formula weight | 10684.3 |
