2EWP

Crystal structure of Estrogen Related Receptor-3 (ERR-gamma) ligand binding domaind with tamoxifen analog GSK5182

Summary for 2EWP

Entry DOI	10.2210/pdb2ewp/pdb
Descriptor	Estrogen-related receptor gamma, (Z)-4-(1-{4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL}-5-HYDROXY-2-PHENYLPENT-1-ENYL)PHENOL (3 entities in total)
Functional Keywords	tamoxifen, err, estrogen related receptor, orphan receptor, transcription
Biological source	Homo sapiens (human)
Cellular location	Nucleus : P62508
Total number of polymer chains	5
Total formula weight	130376.81
Authors	Nolte, R.T. (deposition date: 2005-11-04, release date: 2006-05-09, Last modification date: 2024-04-03)
Primary citation	Chao, E.Y.,Collins, J.L.,Gaillard, S.,Miller, A.B.,Wang, L.,Orband-Miller, L.A.,Nolte, R.T.,McDonnell, D.P.,Willson, T.M.,Zuercher, W.J. Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma. Bioorg.Med.Chem.Lett., 16:821-824, 2006 Cited by PubMed: 16307879 DOI: 10.1016/j.bmcl.2005.11.030 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation