2EU0
The NMR ensemble structure of the Itk SH2 domain bound to a phosphopeptide
Summary for 2EU0
Entry DOI | 10.2210/pdb2eu0/pdb |
Related | 1LUI 1LUK 1LUM 1LUN 2ETZ |
Descriptor | Tyrosine-protein kinase ITK/TSK, Lymphocyte cytosolic protein 2 phosphopeptide fragment (2 entities in total) |
Functional Keywords | cis/trans isomerization, interleukin-2 tyrosine kinase, itk, t-cell specific kinase, tsk, src homology 2, sh2, proline, phosphotyrosine binding, transferase |
Biological source | Mus musculus (house mouse) More |
Cellular location | Cell membrane: Q03526 Cytoplasm (Probable): Q60787 |
Total number of polymer chains | 2 |
Total formula weight | 13354.97 |
Authors | Sundd, M.,Pletneva, E.V.,Fulton, D.B.,Andreotti, A.H. (deposition date: 2005-10-27, release date: 2006-02-07, Last modification date: 2022-03-09) |
Primary citation | Pletneva, E.V.,Sundd, M.,Fulton, D.B.,Andreotti, A.H. Molecular Details of Itk Activation by Prolyl Isomerization and Phospholigand Binding: The NMR Structure of the Itk SH2 Domain Bound to a Phosphopeptide. J.Mol.Biol., 357:550-561, 2006 Cited by PubMed: 16436281DOI: 10.1016/j.jmb.2005.12.073 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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