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2ETK

Crystal Structure of ROCK 1 bound to hydroxyfasudil

Summary for 2ETK
Entry DOI10.2210/pdb2etk/pdb
Related2ERZ 2ESM 2ETO 2ETR
DescriptorRho-associated protein kinase 1, 1-(1-HYDROXY-5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE (2 entities in total)
Functional Keywordsdimer, dimerization, kinase, fasudil, hydroxyfasudil, transferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: Q13464
Total number of polymer chains2
Total formula weight96639.31
Authors
Jacobs, M. (deposition date: 2005-10-27, release date: 2005-11-08, Last modification date: 2023-08-23)
Primary citationJacobs, M.,Hayakawa, K.,Swenson, L.,Bellon, S.,Fleming, M.,Taslimi, P.,Doran, J.
The Structure of Dimeric ROCK I Reveals the Mechanism for Ligand Selectivity.
J.Biol.Chem., 281:260-268, 2006
Cited by
PubMed: 16249185
DOI: 10.1074/jbc.M508847200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.96 Å)
Structure validation

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