2ESV

Structure of the HLA-E-VMAPRTLIL/KK50.4 TCR complex

Summary for 2ESV

• Entry DOI: 10.2210/pdb2esv/pdb
• Descriptor: HLA class I histocompatibility antigen, alpha chain E, Beta-2-microglobulin, VMAPRTLIL peptide from CMV gpUL40, ... (7 entities in total)
• Functional Keywords: t cell receptor, tcr, hla-e, cmv, pmhc-tcr complex, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane; Single-pass type I membrane protein: P13747; Secreted: P61769; Membrane; Single-pass membrane protein (Potential): P01848 P01850
• Total number of polymer chains: 5
• Total formula weight: 94899.38

Authors

Hoare, H.L.,Rossjohn, J. (deposition date: 2005-10-27, release date: 2006-03-21, Last modification date: 2024-10-30)

Primary citation

Hoare, H.L.,Sullivan, L.C.,Pietra, G.,Clements, C.S.,Lee, E.J.,Ely, L.K.,Beddoe, T.,Falco, M.,Kjer-Nielsen, L.,Reid, H.H.,McCluskey, J.,Moretta, L.,Rossjohn, J.,Brooks, A.G.
Structural basis for a major histocompatibility complex class Ib-restricted T cell response
Nat.Immunol., 7:256-264, 2006

PubMed Abstract: In contrast to antigen-specific immunity orchestrated by major histocompatibility complex (MHC) class Ia molecules, the ancestrally related nonclassical MHC class Ib molecules generally mediate innate immune responses. Here we have demonstrated the structural basis by which the MHC class Ib molecule HLA-E mediates an adaptive MHC-restricted cytotoxic T lymphocyte response to human cytomegalovirus. Highly constrained by host genetics, the response showed notable fine specificity for position 8 of the viral peptide, which is the sole discriminator of self versus nonself. Despite the evolutionary divergence of MHC class Ia and class Ib molecules, the structure of the T cell receptor-MHC class Ib complex was very similar to that of conventional T cell receptor-MHC class Ia complexes. These results emphasize the evolutionary 'ambiguity' of HLA-E, which not only interacts with innate immune receptors but also has the functional capacity to mediate virus-specific cytotoxic T lymphocyte responses during adaptive immunity.

PubMed: 16474394
DOI: 10.1038/ni1312

Experimental method

X-RAY DIFFRACTION (2.6 Å)