2ERZ
Crystal Structure of c-AMP Dependent Kinase (PKA) bound to hydroxyfasudil
Summary for 2ERZ
Entry DOI | 10.2210/pdb2erz/pdb |
Related | 2ESM 2ETK 2ETO 2ETR |
Descriptor | cAMP-dependent protein kinase, alpha-catalytic subunit, cAMP-dependent protein kinase inhibitor, alpha form, 1-(1-HYDROXY-5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE, ... (4 entities in total) |
Functional Keywords | fasudil kinase, transferase |
Biological source | Mus musculus (house mouse) More |
Cellular location | Cytoplasm (By similarity): P05132 |
Total number of polymer chains | 2 |
Total formula weight | 43322.29 |
Authors | Jacobs, M. (deposition date: 2005-10-25, release date: 2005-11-08, Last modification date: 2023-08-23) |
Primary citation | Jacobs, M.,Hayakawa, K.,Swenson, L.,Bellon, S.,Fleming, M.,Taslimi, P.,Doran, J. The Structure of Dimeric ROCK I Reveals the Mechanism for Ligand Selectivity. J.Biol.Chem., 281:260-268, 2006 Cited by PubMed: 16249185DOI: 10.1074/jbc.M508847200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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