2ERZ

Crystal Structure of c-AMP Dependent Kinase (PKA) bound to hydroxyfasudil

Summary for 2ERZ

• Entry DOI: 10.2210/pdb2erz/pdb
• Related: 2ESM 2ETK 2ETO 2ETR
• Descriptor: cAMP-dependent protein kinase, alpha-catalytic subunit, cAMP-dependent protein kinase inhibitor, alpha form, 1-(1-HYDROXY-5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE, ... (4 entities in total)
• Functional Keywords: fasudil kinase, transferase
• Biological source: Mus musculus (house mouse); More
• Cellular location: Cytoplasm (By similarity): P05132
• Total number of polymer chains: 2
• Total formula weight: 43322.29

Authors

Jacobs, M. (deposition date: 2005-10-25, release date: 2005-11-08, Last modification date: 2023-08-23)

• Primary citation: Jacobs, M.,Hayakawa, K.,Swenson, L.,Bellon, S.,Fleming, M.,Taslimi, P.,Doran, J.; The Structure of Dimeric ROCK I Reveals the Mechanism for Ligand Selectivity.; J.Biol.Chem., 281:260-268, 2006; PubMed: 16249185; DOI: 10.1074/jbc.M508847200

Experimental method

X-RAY DIFFRACTION (2.2 Å)