2ERZ
Crystal Structure of c-AMP Dependent Kinase (PKA) bound to hydroxyfasudil
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (E) | cAMP-dependent protein kinase, alpha-catalytic subunit | polymer | 351 | 40788.5 | 1 | UniProt (P05132) Pfam (PF00069) | Mus musculus (house mouse) | PKA C-alpha |
| 2 | B (I) | cAMP-dependent protein kinase inhibitor, alpha form | polymer | 20 | 2226.4 | 1 | UniProt (P61926) | PKI-alpha, cAMP- dependent protein kinase inhibitor, muscle/brain isoform | |
| 3 | C (E) | 1-(1-HYDROXY-5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE | non-polymer | 307.4 | 1 | Chemie (HFS) | |||
| 4 | D, E (E, I) | water | water | 18.0 | 61 | Chemie (HOH) |
Sequence modifications
E: 0 - 350 (UniProt: P05132)
| PDB | External Database | Details |
|---|---|---|
| Tpo 197 | Thr 197 | modified residue |
| Sep 338 | Ser 338 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43014.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 307.4 | |
| All* | Total formula weight | 43322.3 |
