2EJR

LSD1-tranylcypromine complex

2EJR の概要

• エントリーDOI: 10.2210/pdb2ejr/pdb
• 関連するPDBエントリー: 2COM 2HKO 2IW5
• 分子名称: Lysine-specific histone demethylase 1, [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL (2R,3S,4S)-5-[7,8-DIMETHYL-2,4-DIOXO-5-(3-PHENYLPROPANOYL)-1,3,4,5-TETRAHYDROBENZO[G]PTERIDIN-10(2H)-YL]-2,3,4-TRIHYDROXYPENTYL DIHYDROGEN DIPHOSPHATE (3 entities in total)
• 機能のキーワード: tower domain, lsd1, fad, tranylcypromine, parnate, amine oxidase, histone, demethylase, alternative splicing, chromatin regulator, coiled coil, nucleus, oxidoreductase, phosphorylation, repressor, transcription, transcription regulation, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: O60341
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 74571.97

構造登録者

Sengoku, T.,Mimasu, S.,Umehara, T.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (登録日: 2007-03-20, 公開日: 2008-01-01, 最終更新日: 2023-10-25)

• 主引用文献: Mimasu, S.,Sengoku, T.,Fukuzawa, S.,Umehara, T.,Yokoyama, S.; Crystal structure of histone demethylase LSD1 and tranylcypromine at 2.25A; Biochem.Biophys.Res.Commun., 366:15-22, 2008; PubMed: 18039463; DOI: 10.1016/j.bbrc.2007.11.066

実験手法

X-RAY DIFFRACTION (2.7 Å)