2EJR
LSD1-tranylcypromine complex
Summary for 2EJR
Entry DOI | 10.2210/pdb2ejr/pdb |
Related | 2COM 2HKO 2IW5 |
Descriptor | Lysine-specific histone demethylase 1, [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL (2R,3S,4S)-5-[7,8-DIMETHYL-2,4-DIOXO-5-(3-PHENYLPROPANOYL)-1,3,4,5-TETRAHYDROBENZO[G]PTERIDIN-10(2H)-YL]-2,3,4-TRIHYDROXYPENTYL DIHYDROGEN DIPHOSPHATE (3 entities in total) |
Functional Keywords | tower domain, lsd1, fad, tranylcypromine, parnate, amine oxidase, histone, demethylase, alternative splicing, chromatin regulator, coiled coil, nucleus, oxidoreductase, phosphorylation, repressor, transcription, transcription regulation, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: O60341 |
Total number of polymer chains | 1 |
Total formula weight | 74571.97 |
Authors | Sengoku, T.,Mimasu, S.,Umehara, T.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2007-03-20, release date: 2008-01-01, Last modification date: 2023-10-25) |
Primary citation | Mimasu, S.,Sengoku, T.,Fukuzawa, S.,Umehara, T.,Yokoyama, S. Crystal structure of histone demethylase LSD1 and tranylcypromine at 2.25A Biochem.Biophys.Res.Commun., 366:15-22, 2008 Cited by PubMed: 18039463DOI: 10.1016/j.bbrc.2007.11.066 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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