2DV0
Human Aldose Reductase complexed with zopolrestat after 6 days soaking(6days_soaked_2)
Summary for 2DV0
Entry DOI | 10.2210/pdb2dv0/pdb |
Related | 2DUX 2DUZ 2FZ8 2FZ9 |
Descriptor | Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID, ... (4 entities in total) |
Functional Keywords | tim barrel, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P15121 |
Total number of polymer chains | 1 |
Total formula weight | 37061.12 |
Authors | Steuber, H.,Heine, A.,Klebe, G. (deposition date: 2006-07-28, release date: 2006-10-03, Last modification date: 2023-10-25) |
Primary citation | Steuber, H.,Zentgraf, M.,Gerlach, C.,Sotriffer, C.A.,Heine, A.,Klebe, G. Expect the Unexpected or Caveat for Drug Designers: Multiple Structure Determinations Using Aldose Reductase Crystals Treated under Varying Soaking and Co-crystallisation Conditions J.Mol.Biol., 363:174-187, 2006 Cited by PubMed: 16952371DOI: 10.1016/j.jmb.2006.08.011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.62 Å) |
Structure validation
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