2DUX

Crystal structure of human Aldose Reductase complexed with zopolrestat after 3 days soaking (3days_soaked_1)

Summary for 2DUX

Entry DOI	10.2210/pdb2dux/pdb
Related	2DUZ 2DV0 2FZ8 2FZ9
Descriptor	Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID, ... (4 entities in total)
Functional Keywords	tim-barrel, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P15121
Total number of polymer chains	1
Total formula weight	37061.12
Authors	Steuber, H.,Heine, A.,Klebe, G. (deposition date: 2006-07-27, release date: 2006-10-03, Last modification date: 2023-10-25)
Primary citation	Steuber, H.,Zentgraf, M.,Gerlach, C.,Sotriffer, C.A.,Heine, A.,Klebe, G. Expect the Unexpected or Caveat for Drug Designers: Multiple Structure Determinations Using Aldose Reductase Crystals Treated under Varying Soaking and Co-crystallisation Conditions J.Mol.Biol., 363:174-187, 2006 Cited by PubMed: 16952371 DOI: 10.1016/j.jmb.2006.08.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation