2DTS

Crystal Structure of the Defucosylated Fc Fragment from Human Immunoglobulin G1

Summary for 2DTS

• Entry DOI: 10.2210/pdb2dts/pdb
• Related: 1E4K 1H3X 1HZH 1L6X 1T83 2DTQ
• Descriptor: Ig gamma-1 chain C region, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: immunoglobulin, igg1, defucosylated glycoform, immune system
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P01857
• Total number of polymer chains: 2
• Total formula weight: 52626.09

Authors

Matsumiya, S.,Yamaguchi, Y.,Saito, J.,Nagano, M.,Sasakawa, H.,Otaki, S.,Satoh, M.,Shitara, K.,Kato, K. (deposition date: 2006-07-14, release date: 2007-03-13, Last modification date: 2023-10-25)

• Primary citation: Matsumiya, S.,Yamaguchi, Y.,Saito, J.,Nagano, M.,Sasakawa, H.,Otaki, S.,Satoh, M.,Shitara, K.,Kato, K.; Structural comparison of fucosylated and nonfucosylated fc fragments of human immunoglobulin g1; J.Mol.Biol., 368:767-779, 2007; PubMed: 17368483; DOI: 10.1016/j.jmb.2007.02.034

Experimental method

X-RAY DIFFRACTION (2.2 Å)