Thermodynamic Penalty Arising From Burial of a Ligand Polar Group Within a Hydrophobic Pocket of a Protein Receptor

Summary for 2DM5

DescriptorMajor Urinary Protein, CADMIUM ION, OCTANE-1,8-DIOL, ... (4 entities in total)
Functional Keywordsbeta barrel, lipocalin, transport protein
Biological sourceMus musculus (house mouse)
Cellular locationSecreted P11589
Total number of polymer chains1
Total molecular weight20735.27
Barratt, E.,Bronowska, A.,Vondrasek, J.,Bingham, R.,Phillips, S.,Homans, S.W. (deposition date: 2006-04-20, release date: 2006-10-17, Last modification date: 2011-07-13)
Primary citation
Barratt, E.,Bronowska, A.,Vondrasek, J.,Cerny, J.,Bingham, R.,Phillips, S.,Homans, S.W.
Thermodynamic penalty arising from burial of a ligand polar group within a hydrophobic pocket of a protein receptor
J.Mol.Biol., 362:994-1003, 2006
PubMed: 16935302 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2006.07.067
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.188130 4.3% 10.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-10-21