2DHF
CRYSTAL STRUCTURES OF RECOMBINANT HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND 5-DEAZOFOLATE
Summary for 2DHF
Entry DOI | 10.2210/pdb2dhf/pdb |
Descriptor | DIHYDROFOLATE REDUCTASE, 5-DEAZAFOLIC ACID (3 entities in total) |
Functional Keywords | oxido-reductase, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Mitochondrion : P00374 |
Total number of polymer chains | 2 |
Total formula weight | 43579.87 |
Authors | Davies /II, J.F.,Kraut, J. (deposition date: 1989-10-25, release date: 1990-07-15, Last modification date: 2024-02-14) |
Primary citation | Davies 2nd., J.F.,Delcamp, T.J.,Prendergast, N.J.,Ashford, V.A.,Freisheim, J.H.,Kraut, J. Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate. Biochemistry, 29:9467-9479, 1990 Cited by PubMed: 2248959DOI: 10.1021/bi00492a021 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
Download full validation report