2CN0
Complex of Recombinant Human Thrombin with a Designed Inhibitor
Summary for 2CN0
Entry DOI | 10.2210/pdb2cn0/pdb |
Related PRD ID | PRD_000481 |
Descriptor | PROTHROMBIN PRECURSOR, HIRUDIN IIA, 4-(1R,3AS,4R,8AS,8BR)-[1-DIFLUOROMETHYL-2-(4-FLUOROBENZYL)-3-OXODECAHYDROPYRROLO[3,4-A]PYRROLIZIN-4-YL]BENZAMIDINE, ... (7 entities in total) |
Functional Keywords | acute phase, blood coagulation, calcium-binding, glycoprotein, hydrolase, serine protease, serine protease inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Secreted, extracellular space: P00734 P00734 Secreted: P28503 |
Total number of polymer chains | 3 |
Total formula weight | 34801.78 |
Authors | Hoffmann-Roder, A.,Schweizer, E.,Egger, J.,Seiler, P.,Obst-Sander, U.,Wagner, B.,Kansy, M.,Banner, D.W.,Diederich, F. (deposition date: 2006-05-17, release date: 2006-11-06, Last modification date: 2023-12-13) |
Primary citation | Hoffmann-Roder, A.,Schweizer, E.,Egger, J.,Seiler, P.,Obst-Sander, U.,Wagner, B.,Kansy, M.,Banner, D.W.,Diederich, F. Mapping the Fluorophilicity of a Hydrophobic Pocket: Synthesis and Biological Evaluation of Tricyclic Thrombin Inhibitors Directing Fluorinated Alkyl Groups Into the P Pocket Chemmedchem, 1:1205-, 2006 Cited by PubMed: 17001711DOI: 10.1002/CMDC.200600124 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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