2CN0
Complex of Recombinant Human Thrombin with a Designed Inhibitor
2CN0 の概要
エントリーDOI | 10.2210/pdb2cn0/pdb |
関連するBIRD辞書のPRD_ID | PRD_000481 |
分子名称 | PROTHROMBIN PRECURSOR, HIRUDIN IIA, 4-(1R,3AS,4R,8AS,8BR)-[1-DIFLUOROMETHYL-2-(4-FLUOROBENZYL)-3-OXODECAHYDROPYRROLO[3,4-A]PYRROLIZIN-4-YL]BENZAMIDINE, ... (7 entities in total) |
機能のキーワード | acute phase, blood coagulation, calcium-binding, glycoprotein, hydrolase, serine protease, serine protease inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
由来する生物種 | HOMO SAPIENS (HUMAN) 詳細 |
細胞内の位置 | Secreted, extracellular space: P00734 P00734 Secreted: P28503 |
タンパク質・核酸の鎖数 | 3 |
化学式量合計 | 34801.78 |
構造登録者 | Hoffmann-Roder, A.,Schweizer, E.,Egger, J.,Seiler, P.,Obst-Sander, U.,Wagner, B.,Kansy, M.,Banner, D.W.,Diederich, F. (登録日: 2006-05-17, 公開日: 2006-11-06, 最終更新日: 2023-12-13) |
主引用文献 | Hoffmann-Roder, A.,Schweizer, E.,Egger, J.,Seiler, P.,Obst-Sander, U.,Wagner, B.,Kansy, M.,Banner, D.W.,Diederich, F. Mapping the Fluorophilicity of a Hydrophobic Pocket: Synthesis and Biological Evaluation of Tricyclic Thrombin Inhibitors Directing Fluorinated Alkyl Groups Into the P Pocket Chemmedchem, 1:1205-, 2006 Cited by PubMed: 17001711DOI: 10.1002/CMDC.200600124 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.3 Å) |
構造検証レポート
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