2CN0

Complex of Recombinant Human Thrombin with a Designed Inhibitor

2CN0 の概要

• エントリーDOI: 10.2210/pdb2cn0/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000481
• 分子名称: PROTHROMBIN PRECURSOR, HIRUDIN IIA, 4-(1R,3AS,4R,8AS,8BR)-[1-DIFLUOROMETHYL-2-(4-FLUOROBENZYL)-3-OXODECAHYDROPYRROLO[3,4-A]PYRROLIZIN-4-YL]BENZAMIDINE, ... (7 entities in total)
• 機能のキーワード: acute phase, blood coagulation, calcium-binding, glycoprotein, hydrolase, serine protease, serine protease inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• 細胞内の位置: Secreted, extracellular space: P00734 P00734; Secreted: P28503
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 34801.78

構造登録者

Hoffmann-Roder, A.,Schweizer, E.,Egger, J.,Seiler, P.,Obst-Sander, U.,Wagner, B.,Kansy, M.,Banner, D.W.,Diederich, F. (登録日: 2006-05-17, 公開日: 2006-11-06, 最終更新日: 2023-12-13)

• 主引用文献: Hoffmann-Roder, A.,Schweizer, E.,Egger, J.,Seiler, P.,Obst-Sander, U.,Wagner, B.,Kansy, M.,Banner, D.W.,Diederich, F.; Mapping the Fluorophilicity of a Hydrophobic Pocket: Synthesis and Biological Evaluation of Tricyclic Thrombin Inhibitors Directing Fluorinated Alkyl Groups Into the P Pocket; Chemmedchem, 1:1205-, 2006; PubMed: 17001711; DOI: 10.1002/CMDC.200600124

実験手法

X-RAY DIFFRACTION (1.3 Å)