2CGN

FACTOR INHIBITING HIF-1 ALPHA with succinate

Summary for 2CGN

Entry DOI	10.2210/pdb2cgn/pdb
Related	1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGO
Descriptor	HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR, FE (III) ION, SUCCINIC ACID, ... (5 entities in total)
Functional Keywords	2-oxoglutarate, acetylation, activator, oxidoreductase, alternative splicing, asparaginyl hydroxylase, dna-binding, dsbh, fi, hif, hydroxylation, hypoxia, nuclear protein, oxygenase, phosphorylation, polymorphism, s-nitrosylation, transcription, transcription activator/inhibitor, transcription regulation
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Nucleus: Q9NWT6
Total number of polymer chains	1
Total formula weight	40886.47
Authors	McDonough, M.A.,Clifton, I.J.,Schofield, C.J. (deposition date: 2006-03-09, release date: 2006-12-13, Last modification date: 2023-12-13)
Primary citation	Hewitson, K.,Lienard, B.,McDonough, M.A.,Clifton, I.J.,Butler, D.,Soares, A.S.,Oldham, N.J.,McNeill, L.A.,Schofield, C.J. Structural and Mechanistic Studies on the Inhibition of the Hypoxia-Inducible Transcription Factor Hydroxylases by Tricarboxylic Acid Cycle Intermediates. J.Biol.Chem., 282:3293-3301, 2007 Cited by PubMed: 17135241 DOI: 10.1074/JBC.M608337200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation