2CGN

FACTOR INHIBITING HIF-1 ALPHA with succinate

2CGN の概要

• エントリーDOI: 10.2210/pdb2cgn/pdb
• 関連するPDBエントリー: 1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGO
• 分子名称: HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR, FE (III) ION, SUCCINIC ACID, ... (5 entities in total)
• 機能のキーワード: 2-oxoglutarate, acetylation, activator, oxidoreductase, alternative splicing, asparaginyl hydroxylase, dna-binding, dsbh, fi, hif, hydroxylation, hypoxia, nuclear protein, oxygenase, phosphorylation, polymorphism, s-nitrosylation, transcription, transcription activator/inhibitor, transcription regulation
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Nucleus: Q9NWT6
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40886.47

構造登録者

McDonough, M.A.,Clifton, I.J.,Schofield, C.J. (登録日: 2006-03-09, 公開日: 2006-12-13, 最終更新日: 2023-12-13)

• 主引用文献: Hewitson, K.,Lienard, B.,McDonough, M.A.,Clifton, I.J.,Butler, D.,Soares, A.S.,Oldham, N.J.,McNeill, L.A.,Schofield, C.J.; Structural and Mechanistic Studies on the Inhibition of the Hypoxia-Inducible Transcription Factor Hydroxylases by Tricarboxylic Acid Cycle Intermediates.; J.Biol.Chem., 282:3293-3301, 2007; PubMed: 17135241; DOI: 10.1074/JBC.M608337200

実験手法

X-RAY DIFFRACTION (2.4 Å)