2CEN
P1' Extended HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol in the Transition-State Mimicking Scaffold
Summary for 2CEN
Entry DOI | 10.2210/pdb2cen/pdb |
Related | 1WBK 1WBM 2CEJ 2CEM |
Descriptor | POL PROTEIN, {(1S)-1-[N'-[(2S)-2-HYDROXY-2-((1S,2R)-2-HYDROXY-INDAN-1-YLCARBAMOYL)-3-PHENYL-PROPYL]-N'-[4-(PYRIDINE-2-YL)-BENZYL]-HYDRAZINOCARBONYL]-2,2-DIMETHYL-PROPYL}-CARBAMIC ACID METHYL ESTER (3 entities in total) |
Functional Keywords | hiv-1, protease, inhibitor, aspartyl protease, hydrolase |
Biological source | HUMAN IMMUNODEFICIENCY VIRUS 1 |
Total number of polymer chains | 2 |
Total formula weight | 22287.32 |
Authors | Ginman, N.,Ekegren, J.K.,Johansson, A.,Wallberg, H.,Larhed, M.,Samuelsson, B.,Hallberg, A.,Unge, T. (deposition date: 2006-02-08, release date: 2007-02-13, Last modification date: 2023-12-13) |
Primary citation | Ekegren, J.K.,Ginman, N.,Johansson, A.,Wallberg, H.,Larhed, M.,Samuelsson, B.,Unge, T.,Hallberg, A. Microwave-Accelerated Synthesis of P1'-Extended HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol in the Transition-State Mimicking Scaffold. J.Med.Chem., 49:1828-, 2006 Cited by PubMed: 16509598DOI: 10.1021/JM051239Z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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