2C3I

CRYSTAL STRUCTURE OF HUMAN PIM1 IN COMPLEX WITH IMIDAZOPYRIDAZIN I

2C3I の概要

• エントリーDOI: 10.2210/pdb2c3i/pdb
• 関連するPDBエントリー: 1XQZ 1XR1 1XWS 1YHS 1YI3 1YI4 1YWV 1YXS 1YXT 1YXU 1YXV 1YXX 2BIK 2BIL 2BZH 2BZI 2BZJ 2BZK
• 分子名称: PIMTIDE, PROTO-ONCOGENE SERINE THREONINE PROTEIN KINASE PIM1, 1-(3-{6-[(CYCLOPROPYLMETHYL)AMINO]IMIDAZO[1,2-B]PYRIDAZIN-3-YL}PHENYL)ETHANONE, ... (4 entities in total)
• 機能のキーワード: transferase-peptide complex, complex transferase-peptide, pim1, kinase, cancer, leukemia, atp-binding, nuclear protein, nucleotide-binding, phosphorylation, proto- oncogene, serine/threonine-protein kinase, transferase, transferase/peptide
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• 細胞内の位置: Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 36937.13

構造登録者

Philippakopoulos, P.,Knapp, S.,Debreczeni, J.,Bullock, A.,von Delft, F.,Sundstrom, M.,Arrowsmith, C.,Edwards, A.,Guo, K.,Weigelt, J. (登録日: 2005-10-07, 公開日: 2005-11-01, 最終更新日: 2023-12-13)

• 主引用文献: Pogacic, V.,Bullock, A.N.,Fedorov, O.,Filippakopoulos, P.,Gasser, C.,Biondi, A.,Meyer-Monard, S.,Knapp, S.,Schwaller, J.; Structural Analysis Identifies Imidazo[1,2- B]Pyridazines as Pim Kinase Inhibitors with in Vitro Antileukemic Activity.; Cancer Res., 67:6916-, 2007; PubMed: 17638903; DOI: 10.1158/0008-5472.CAN-07-0320

実験手法

X-RAY DIFFRACTION (1.9 Å)