2BZG

Crystal structure of thiopurine S-methyltransferase.

Summary for 2BZG

DescriptorTHIOPURINE S-METHYLTRANSFERASE, S-ADENOSYL-L-HOMOCYSTEINE, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total)
Functional Keywordsmethyltransferase, polymorphism, transferase, psi, protein structure initiative, structural genomics consortium (sgc)
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm P51580
Total number of polymer chains1
Total molecular weight27454.09
Authors
Primary citation
Wu, H.,Horton, J.R.,Battaile, K.P.,Allali-Hassani, A.,Martin, F.,Zeng, H.,Loppnau, P.,Vedadi, M.,Bochkarev, A.,Plotnikov, A.N.,Cheng, X.
Structural Basis of Allele Variation of Human Thiopurine-S-Methyltransferase.
Proteins, 67:198-, 2007
PubMed: 17243178 (PDB entries with the same primary citation)
DOI: 10.1002/PROT.21272
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.58 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers401.5%0.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2bzg
no rotation
Molmil generated image of 2bzg
rotated about x axis by 90°
Molmil generated image of 2bzg
rotated about y axis by 90°
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