2BU5

crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands

2BU5 の概要

• エントリーDOI: 10.2210/pdb2bu5/pdb
• 関連するPDBエントリー: 2BTZ 2BU2 2BU6 2BU7 2BU8
• 分子名称: PYRUVATE DEHYDROGENASE KINASE ISOENZYME 2, 4-({(2R,5S)-2,5-DIMETHYL-4-[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]PIPERAZIN-1-YL}CARBONYL)BENZONITRILE (3 entities in total)
• 機能のキーワード: transferase, pyruvate dehydrogenase kinase 2, ghkl motif regulation
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 45031.10

構造登録者

Knoechel, T.R.,Tucker, A.D.,Robinson, C.M.,Phillips, C.,Taylor, W.,Bungay, P.J.,Kasten, S.A.,Roche, T.E.,Brown, D.G. (登録日: 2005-06-08, 公開日: 2006-02-02, 最終更新日: 2023-12-13)

• 主引用文献: Knoechel, T.R.,Tucker, A.D.,Robinson, C.M.,Phillips, C.,Taylor, W.,Bungay, P.J.,Kasten, S.A.,Roche, T.E.,Brown, D.G.; Regulatory Roles of the N-Terminal Domain Based on Crystal Structures of Human Pyruvate Dehydrogenase Kinase 2 Containing Physiological and Synthetic Ligands.; Biochemistry, 45:402-, 2006; PubMed: 16401071; DOI: 10.1021/BI051402S

実験手法

X-RAY DIFFRACTION (2.35 Å)