2BPV

HIV-1 protease-inhibitor complex

Summary for 2BPV

Entry DOI	10.2210/pdb2bpv/pdb
Descriptor	HIV-1 PROTEASE, 1-[2-HYDROXY-4-(2-HYDROXY-5-METHYL-CYCLOPENTYLCARBAMOYL)5-PHENYL-PENTYL]-4-(3-PYRIDIN-3-YL-PROPIONYL)-PIPERAZINE-2-CARB OXYLIC ACID TERT-BUTYLAMIDE (3 entities in total)
Functional Keywords	acid protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus 1
Cellular location	Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04587
Total number of polymer chains	2
Total formula weight	22229.32
Authors	Munshi, S.,Chen, Z. (deposition date: 1998-01-22, release date: 1999-02-23, Last modification date: 2024-02-14)
Primary citation	Munshi, S.,Chen, Z.,Li, Y.,Olsen, D.B.,Fraley, M.E.,Hungate, R.W.,Kuo, L.C. Rapid X-ray diffraction analysis of HIV-1 protease-inhibitor complexes: inhibitor exchange in single crystals of the bound enzyme. Acta Crystallogr.,Sect.D, 54:1053-1060, 1998 Cited by PubMed: 9757136 DOI: 10.1107/S0907444998003588 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation