2BLA

SP21 double mutant P. vivax Dihydrofolate reductase in complex with pyrimethamine

2BLA の概要

• エントリーDOI: 10.2210/pdb2bla/pdb
• 関連するPDBエントリー: 1J3I 1J3J 1J3K 2BL9 2BLB 2BLC
• 分子名称: DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE, ... (5 entities in total)
• 機能のキーワード: dihydrofolate reductase, plasmodium vivax, pyrimethamine, malaria, drug resistance, oxidoreductase
• 由来する生物種: PLASMODIUM VIVAX
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28455.54

構造登録者

Kongsaeree, P.,Khongsuk, P.,Leartsakulpanich, U.,Chitnumsub, P.,Tarnchompoo, B.,Walkinshaw, M.D.,Yuthavong, Y. (登録日: 2005-03-02, 公開日: 2005-09-07, 最終更新日: 2024-05-08)

• 主引用文献: Kongsaeree, P.,Khongsuk, P.,Leartsakulpanich, U.,Chitnumsub, P.,Tarnchompoo, B.,Walkinshaw, M.D.,Yuthavong, Y.; Crystal Structure of Dihydrofolate Reductase from Plasmodium Vivax: Pyrimethamine Displacement Linked with Mutation-Induced Resistance.; Proc.Natl.Acad.Sci.USA, 102:13046-, 2005; PubMed: 16135570; DOI: 10.1073/PNAS.0501747102

実験手法

X-RAY DIFFRACTION (2.5 Å)