Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 29 |
| Details | binding site for residue NDP A 301 |
| Chain | Residue |
| A | CYS14 |
| A | ARG115 |
| A | SER116 |
| A | ASN117 |
| A | TYR125 |
| A | LEU136 |
| A | SER137 |
| A | LYS138 |
| A | THR139 |
| A | ASP153 |
| A | ILE173 |
| A | ALA15 |
| A | GLY174 |
| A | GLY175 |
| A | GLN177 |
| A | VAL178 |
| A | GLU181 |
| A | CP6302 |
| A | HOH403 |
| A | HOH418 |
| A | HOH424 |
| A | HOH470 |
| A | LEU39 |
| A | GLY43 |
| A | THR44 |
| A | LEU45 |
| A | TRP47 |
| A | ARG58 |
| A | GLY114 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue CP6 A 302 |
| Chain | Residue |
| A | ILE13 |
| A | CYS14 |
| A | ALA15 |
| A | ASP53 |
| A | PHE57 |
| A | ASN117 |
| A | ILE173 |
| A | TYR179 |
| A | THR194 |
| A | NDP301 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue MES A 303 |
| Chain | Residue |
| A | PHE57 |
| A | ARG58 |
| A | LEU128 |
| A | ARG131 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 24 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. GLGnkgtLPWkcnsvDmkyFrsvT |
| Chain | Residue | Details |
| A | GLY38-THR61 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 11 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ILE13 | |
| A | TYR179 | |
| A | THR194 | |
| A | ALA15 | |
| A | GLY38 | |
| A | ASP53 | |
| A | ARG115 | |
| A | SER137 | |
| A | ASP153 | |
| A | ILE173 | |
| A | GLY174 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dhf |
| Chain | Residue | Details |
| A | LEU45 | |
| A | ASP53 | |
