2BLA
SP21 double mutant P. vivax Dihydrofolate reductase in complex with pyrimethamine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE | polymer | 238 | 27266.2 | 1 | UniProt (Q5U9H1) Pfam (PF00186) UniProt (by SIFTS) (O02604) | PLASMODIUM VIVAX | DIHYDROFOLATE REDUCTASE |
| 2 | B (A) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 3 | C (A) | 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE | non-polymer | 248.7 | 1 | Chemie (CP6) | |||
| 4 | D (A) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 5 | E (A) | water | water | 18.0 | 151 | Chemie (HOH) |
Sequence modifications
A: 1 - 237 (UniProt: Q5U9H1)
A: 238 - 238 (PDB: 2BLA)
| PDB | External Database | Details |
|---|---|---|
| Asn 3 | Asp 3 | conflict |
| Glu 213 | Gln 213 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 27266.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1189.4 | |
| All* | Total formula weight | 28455.5 |
