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2BKK

Crystal structure of Aminoglycoside Phosphotransferase APH(3')-IIIa in complex with the inhibitor AR_3a

Summary for 2BKK
Entry DOI10.2210/pdb2bkk/pdb
Related1J7I 1J7L 1J7U 1K1A 1K1B 1L8T 1L8U 1MJ0 1N0Q 1N0R 2BKG
DescriptorAMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE, DESIGNED ANKYRIN REPEAT INHIBITOR AR_3A, ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
Functional Keywordstransferase/peptide, transferase-designed protein complex, ankyrin repeat, co-crystallization, inhibitor design, drug design, enzyme inhibition, kinase inhibition, designed repeat protein, antibiotic resistance, atp-binding, kinase, plasmid, transferase, transferase-peptide complex
Biological sourceENTEROCOCCUS FAECALIS
More
Total number of polymer chains4
Total formula weight100117.13
Authors
Kohl, A.,Amstutz, P.,Parizek, P.,Binz, H.K.,Briand, C.,Capitani, G.,Forrer, P.,Pluckthun, A.,Grutter, M.G. (deposition date: 2005-02-16, release date: 2005-08-09, Last modification date: 2023-12-13)
Primary citationKohl, A.,Amstutz, P.,Parizek, P.,Binz, H.K.,Briand, C.,Capitani, G.,Forrer, P.,Pluckthun, A.,Grutter, M.G.
Allosteric Inhibition of Aminoglycoside Phosphotransferase by a Designed Ankyrin Repeat Protein
Structure, 13:1131-, 2005
Cited by
PubMed: 16084385
DOI: 10.1016/J.STR.2005.04.020
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.15 Å)
Structure validation

217705

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