2BJS

Isopenicillin N synthase C-terminal truncation mutant

2BJS の概要

• エントリーDOI: 10.2210/pdb2bjs/pdb
• 関連するPDBエントリー: 1BK0 1BLZ 1HB1 1HB2 1HB3 1HB4 1IPS 1OBN 1OC1 1ODM 1ODN 1QIQ 1QJE 1QJF 1UZW 1W03 1W04 1W05 1W06 1W3V 1W3X 2BU9
• 分子名称: ISOPENICILLIN N SYNTHETASE, FE (III) ION, L-D-(A-AMINOADIPOYL)-L-CYSTEINYL-D-VALINE, ... (6 entities in total)
• 機能のキーワード: oxidoreductase, antibiotic biosynthesis, b-lactam antibiotic, iron, oxygenase, penicillin biosynthesis, vitamin c
• 由来する生物種: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37847.04

構造登録者

McNeill, L.A.,Sami, M.,Clifton, I.J.,Burzlaff, N.I. (登録日: 2005-02-07, 公開日: 2006-03-09, 最終更新日: 2024-05-08)

• 主引用文献: McNeill, L.A.,Brown, T.J.N.,Sami, M.,Clifton, I.J.,Burzlaff, N.I.,Claridge, T.D.W.,Adlington, R.M.,Baldwin, J.E.,Rutledge, P.J.,Schofield, C.J.; Terminally Truncated Isopenicillin N Synthase Generates a Dithioester Product: Evidence for a Thioaldehyde Intermediate during Catalysis and a New Mode of Reaction for Non-Heme Iron Oxidases.; Chemistry, 23:12815-12824, 2017; PubMed: 28703303; DOI: 10.1002/chem.201701592

実験手法

X-RAY DIFFRACTION (1.3 Å)