Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0016216 | molecular_function | isopenicillin-N synthase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0017000 | biological_process | antibiotic biosynthetic process |
| A | 0031418 | molecular_function | L-ascorbic acid binding |
| A | 0042318 | biological_process | penicillin biosynthetic process |
| A | 0044283 | biological_process | small molecule biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FE A1323 |
| Chain | Residue |
| A | HIS214 |
| A | ASP216 |
| A | HIS270 |
| A | ACV1324 |
| A | HOH2402 |
| A | HOH2408 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A1327 |
| Chain | Residue |
| A | HOH2301 |
| A | HOH2317 |
| A | HOH2542 |
| A | HOH2543 |
| A | HOH2544 |
| A | HOH2545 |
| A | ARG53 |
| A | ASP140 |
| A | PHE141 |
| site_id | AC3 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE ACV A1324 |
| Chain | Residue |
| A | ARG87 |
| A | TYR91 |
| A | SER183 |
| A | ILE187 |
| A | TYR189 |
| A | PHE211 |
| A | HIS214 |
| A | ASP216 |
| A | LEU223 |
| A | VAL272 |
| A | SER281 |
| A | PRO283 |
| A | PHE285 |
| A | FE1323 |
| A | ACV1325 |
| A | HOH2402 |
| A | HOH2408 |
| A | HOH2533 |
| A | HOH2534 |
| A | HOH2536 |
| A | HOH2537 |
| A | HOH2538 |
| A | HOH2539 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE ACV A1325 |
| Chain | Residue |
| A | TYR91 |
| A | LYS98 |
| A | GLU101 |
| A | SER102 |
| A | ACV1324 |
| A | MEE1326 |
| A | HOH2189 |
| A | HOH2537 |
| A | HOH2539 |
| A | HOH2540 |
| A | HOH2541 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MEE A1326 |
| Chain | Residue |
| A | ACV1325 |
| A | HOH2014 |
| A | HOH2030 |
Functional Information from PROSITE/UniProt
| site_id | PS00185 |
| Number of Residues | 10 |
| Details | IPNS_1 Isopenicillin N synthase signature 1. KkAveSfCYL |
| Chain | Residue | Details |
| A | LYS97-LEU106 | |
| site_id | PS00186 |
| Number of Residues | 14 |
| Details | IPNS_2 Isopenicillin N synthase signature 2. LInCGSymAhlTnN |
| Chain | Residue | Details |
| A | LEU250-ASN263 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | ARG87 | |
| A | TYR91 | |
| A | TYR189 | |
| A | ASP216 | |
| A | SER281 | |
| Chain | Residue | Details |
| A | SER183 | |
| Chain | Residue | Details |
| A | HIS214 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00805, ECO:0007744|PDB:1BK0, ECO:0007744|PDB:1BLZ, ECO:0007744|PDB:1HB1, ECO:0007744|PDB:1HB2, ECO:0007744|PDB:1HB3, ECO:0007744|PDB:1HB4, ECO:0007744|PDB:1OBN, ECO:0007744|PDB:1OC1, ECO:0007744|PDB:1ODM, ECO:0007744|PDB:1ODN, ECO:0007744|PDB:1QIQ, ECO:0007744|PDB:1QJE, ECO:0007744|PDB:1QJF, ECO:0007744|PDB:1UZW, ECO:0007744|PDB:1W03, ECO:0007744|PDB:1W04, ECO:0007744|PDB:1W05, ECO:0007744|PDB:1W06, ECO:0007744|PDB:1W3V, ECO:0007744|PDB:1W3X, ECO:0007744|PDB:2BU9, ECO:0007744|PDB:2IVI, ECO:0007744|PDB:2IVJ, ECO:0007744|PDB:2JB4, ECO:0007744|PDB:2VAU, ECO:0007744|PDB:2VBB, ECO:0007744|PDB:2VBD, ECO:0007744|PDB:2VBP, ECO:0007744|PDB:2VCM, ECO:0007744|PDB:2VE1, ECO:0007744|PDB:2WO7, ECO:0007744|PDB:2Y60, ECO:0007744|PDB:2Y6F, ECO:0007744|PDB:3ZKU, ECO:0007744|PDB:3ZOI, ECO:0007744|PDB:4BB3 |
| Chain | Residue | Details |
| A | HIS270 | |
| Chain | Residue | Details |
| A | ARG279 | |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | SITE: Transition state stabilizer => ECO:0007744|PDB:1QJE |
| Chain | Residue | Details |
| A | PHE211 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qje |
| Chain | Residue | Details |
| A | PHE211 | |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qje |
| Chain | Residue | Details |
| A | LEU186 | |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qje |
| Chain | Residue | Details |
| A | HIS82 | |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qje |
| Chain | Residue | Details |
| A | ILE75 | |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 145 |
| Chain | Residue | Details |
| A | PHE211 | polar/non-polar interaction, steric role |
| A | HIS214 | metal ligand |
| A | ASP216 | metal ligand |
| A | HIS270 | metal ligand |
