2BGC

PrfA-G145S, a constitutive active mutant of the Transcriptional Regulator In L.monocytogenes

Summary for 2BGC

• Entry DOI: 10.2210/pdb2bgc/pdb
• Related: 1OMI 2BEO
• Descriptor: PRFA, (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ... (4 entities in total)
• Functional Keywords: bacterial infection, human pathogen, transcriptional regulator, transcription
• Biological source: LISTERIA MONOCYTOGENES
• Total number of polymer chains: 8
• Total formula weight: 219752.50

Authors

Eiting, M.,Hagelueken, G.,Schubert, W.-D.,Heinz, D.W. (deposition date: 2004-12-20, release date: 2005-04-14, Last modification date: 2023-12-13)

• Primary citation: Eiting, M.,Hagelueken, G.,Schubert, W.-D.,Heinz, D.W.; The Mutation G145S in Prfa, a Key Virulence Regulator of Listeria Monocytogenes, Increases DNA-Binding Affinity by Stabilizing the Hth Motif; Mol.Microbiol., 56:433-, 2005; PubMed: 15813735; DOI: 10.1111/J.1365-2958.2005.04561.X

Experimental method

X-RAY DIFFRACTION (2.3 Å)