2BFX
Mechanism of Aurora-B activation by INCENP and inhibition by Hesperadin.
Summary for 2BFX
Entry DOI | 10.2210/pdb2bfx/pdb |
Related | 2BFY |
Descriptor | AURORA KINASE B-A, INNER CENTROMERE PROTEIN A (3 entities in total) |
Functional Keywords | transferase, kinase, mitosis, inhibition, transferase complex |
Biological source | XENOPUS LAEVIS (AFRICAN CLAWED FROG) More |
Cellular location | Nucleus: Q6DE08 Chromosome, centromere: O13024 |
Total number of polymer chains | 4 |
Total formula weight | 77029.02 |
Authors | Sessa, F.,Mapelli, M.,Ciferri, C.,Tarricone, C.,Areces, L.B.,Schneider, T.R.,Stukenberg, P.T.,Musacchio, A. (deposition date: 2004-12-15, release date: 2005-05-03, Last modification date: 2023-12-13) |
Primary citation | Sessa, F.,Mapelli, M.,Ciferri, C.,Tarricone, C.,Areces, L.B.,Schneider, T.R.,Stukenberg, P.T.,Musacchio, A. Mechanism of Aurora B Activation by Incenp and Inhibition by Hesperadin Mol.Cell, 18:379-, 2005 Cited by PubMed: 15866179DOI: 10.1016/J.MOLCEL.2005.03.031 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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