2BFP
Leishmania major pteridine reductase 1 in complex with NADP and tetrahydrobiopterin
Summary for 2BFP
| Entry DOI | 10.2210/pdb2bfp/pdb |
| Related | 1E7W 1E92 1W0C 2BF7 2BFA 2BFM 2BFO |
| Descriptor | PTERIDINE REDUCTASE 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (5 entities in total) |
| Functional Keywords | pteridine reductase, trypanosomatids, drug resistance, pterin salvage, short-chain dehydrogenase/reductase, methotrexate resistance, nadp, oxidoreductase |
| Biological source | LEISHMANIA MAJOR |
| Total number of polymer chains | 4 |
| Total formula weight | 126073.34 |
| Authors | Schuettelkopf, A.W.,Hunter, W.N. (deposition date: 2004-12-10, release date: 2005-08-31, Last modification date: 2023-12-13) |
| Primary citation | Schuettelkopf, A.W.,Hardy, L.W.,Beverley, S.M.,Hunter, W.N. Structures of Leishmania Major Pteridine Reductase Complexes Reveal the Active Site Features Important for Ligand Binding and to Guide Inhibitor Design J.Mol.Biol., 352:105-, 2005 Cited by PubMed: 16055151DOI: 10.1016/J.JMB.2005.06.076 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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