2B55

Human cyclin dependent kinase 2 (cdk2) complexed with indenopyraxole DIN-101312

Summary for 2B55

Entry DOI	10.2210/pdb2b55/pdb
Related	2B52 2B53 2B54
Descriptor	Cell division protein kinase 2, 2-(4-(AMINOMETHYL)PIPERIDIN-1-YL)-N-(3_CYCLOHEXYL-4-OXO-2,4-DIHYDROINDENO[1,2-C]PYRAZOL-5-YL)ACETAMIDE (3 entities in total)
Functional Keywords	protein kinase, cell cycle, phosphorylation, cell division, mitosis, inhibition, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	34398.02
Authors	Muckelbauer, J. (deposition date: 2005-09-27, release date: 2005-10-11, Last modification date: 2024-02-14)
Primary citation	Yue, E.W.,Higley, C.A.,Dimeo, S.V.,Carini, D.J.,Nugiel, D.A.,Benware, C.,Benfield, P.A.,Cox, S.,Burton, C.R.,Grafstrom, R.H.,Sharp, D.M.,Sisk, L.M.,Boylan, J.F.,Muckelbauer, J.K.,Smallwood, A.M.,Chen, H.,Chang, C.-H.,Seitz, S.P.,Trainor, G.L. Synthesis and Evaluation of Indenopyrazoles as Cyclin-Dependent Kinase Inhibitors. 3. Structure Activity Relationships at C3 J.Med.Chem., 45:5233-5248, 2002 Cited by PubMed: 12431051 DOI: 10.1021/jm0201722 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation