2B52

Human cyclin dependent kinase 2 (CDK2) complexed with DPH-042562

Summary for 2B52

Related2B53 2B54 2B55
DescriptorCell division protein kinase 2, 1-(3-(2,4-DIMETHYLTHIAZOL-5-YL)-4-OXO-2,4-DIHYDROINDENO[1,2-C]PYRAZOL-5-YL)-3-(4-METHYLPIPERAZIN-1-YL)UREA (3 entities in total)
Functional Keywordsprotein kinase, cell cycle, phosphorylation, cell division, mitosis, inhibition, transferase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total molecular weight34414.01
Authors
Muckelbauer, J. (deposition date: 2005-09-27, release date: 2005-10-11, Last modification date: 2011-07-13)
Primary citation
Yue, E.W.,Dimeo, S.V.,Higley, C.A.,Markwalder, J.A.,Burton, C.R.,Benfield, P.A.,Grafstrom, R.H.,Cox, S.,Muckelbauer, J.K.,Smallwood, A.,Chen, H.,Chang, C.-H.,Trainor, G.L.,Seitz, S.P.
Synthesis and Evaluation of Indenopyrazoles as Cyclin-Dependent Kinase Inhibitors. Part 4: Heterocycles at C3
Bioorg.Med.Chem.Lett., 14:343-346, 2004
PubMed: 14698155 (PDB entries with the same primary citation)
DOI: 10.1016/j.bmcl.2003.11.008
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.88 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.281161.4%5.2%17.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report