2B52

Human cyclin dependent kinase 2 (CDK2) complexed with DPH-042562

2B52 の概要

• エントリーDOI: 10.2210/pdb2b52/pdb
• 関連するPDBエントリー: 2B53 2B54 2B55
• 分子名称: Cell division protein kinase 2, 1-(3-(2,4-DIMETHYLTHIAZOL-5-YL)-4-OXO-2,4-DIHYDROINDENO[1,2-C]PYRAZOL-5-YL)-3-(4-METHYLPIPERAZIN-1-YL)UREA (3 entities in total)
• 機能のキーワード: protein kinase, cell cycle, phosphorylation, cell division, mitosis, inhibition, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34414.01

構造登録者

Muckelbauer, J. (登録日: 2005-09-27, 公開日: 2005-10-11, 最終更新日: 2024-02-14)

• 主引用文献: Yue, E.W.,Dimeo, S.V.,Higley, C.A.,Markwalder, J.A.,Burton, C.R.,Benfield, P.A.,Grafstrom, R.H.,Cox, S.,Muckelbauer, J.K.,Smallwood, A.,Chen, H.,Chang, C.-H.,Trainor, G.L.,Seitz, S.P.; Synthesis and Evaluation of Indenopyrazoles as Cyclin-Dependent Kinase Inhibitors. Part 4: Heterocycles at C3; Bioorg.Med.Chem.Lett., 14:343-346, 2004; PubMed: 14698155; DOI: 10.1016/j.bmcl.2003.11.008

実験手法

X-RAY DIFFRACTION (1.88 Å)