2AZ9

HIV-1 Protease NL4-3 1X mutant

2AZ9 の概要

• エントリーDOI: 10.2210/pdb2az9/pdb
• 関連するPDBエントリー: 2AZ8 2AZB 2AZC
• 関連するBIRD辞書のPRD_ID: PRD_000434
• 分子名称: PROTEASE RETROPEPSIN, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate (3 entities in total)
• 機能のキーワード: hiv, protease, inhibitor, tl-3, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11712.86

構造登録者

Heaslet, H.,Kutilek, V.,Morris, G.M.,Lin, Y.-C.,Elder, J.H.,Torbett, B.E.,Stout, C.D. (登録日: 2005-09-09, 公開日: 2006-02-28, 最終更新日: 2023-08-23)

• 主引用文献: Heaslet, H.,Kutilek, V.,Morris, G.M.,Lin, Y.-C.,Elder, J.H.,Torbett, B.E.,Stout, C.D.; Structural Insights into the Mechanisms of Drug Resistance in HIV-1 Protease NL4-3; J.Mol.Biol., 356:967-981, 2006; PubMed: 16403521; DOI: 10.1016/j.jmb.2005.11.094

実験手法

X-RAY DIFFRACTION (2.5 Å)